Road crashes are one of the leading causes of death and injury for children in Vietnam. From September 2010 to April 2014, AIP Foundation, with support from The Atlantic Philanthropies and partners, implemented an integrated campaign to increase the helmet wearing rate of children in three major cities of Vietnam: Hanoi, Danang, and Ho Chi Minh City. AIP Foundation prioritized an evidence-based approach to designing the campaign, which consisted of three components: a wide-scale public awareness campaign, enhanced police enforcement, and partnership and capacity building. This case study details the process of developing and implementing an integrated campaign and shares some of the lessons learned from this process.